Mike gets married and his bride is finally revealed -- will it be Katherine or Susan? Meanwhile, Lynette deals with the realities of being pregnant again; Bree works to break free from Orson; Gaby is tested by Carlos’ niece who continues to stay with them; and a new family with dark secrets moves to Wisteria.

Mrs. McCluskey falls for a steak salesman called Roy Handler. Julie is found unconscious in the park bushes, which questions Mrs. McCluskey’s decision to tell the police that she saw Angie Bolen’s 19-year-old son, Danny, fighting with Julie.

Gaby reunites with her ex-lover-gardener, John Rowland, in a chance encounter. Bree contemplates taking Karl on a weekend getaway. Lynette and Tom break the news to their kids that she’s pregnant again. Susan is convinced her daughter was attacked by Angie’s son.

Having lost Mike has taken its toll on Katherine, as Bree comes to her aid as she unravels. Elsewhere, Gaby has grown weary of John's intentions with Ana, Susan discovers that Julie has been keeping secrets and Angie throws her son, Danny, a party.

When Juanita's party is on the verge of being ruined after Gaby is deemed a bad mom, Gaby is determined to prove she's a responsible parent; Bree gets defensive when she's judged by a motel maid for having an affair with Karl; Lynette is put off by her new handyman when he defers to Tom for approval on all things; and Susan and Katherine come to blows over Mike. Meanwhile, a lapse in judgment on Danny's part leads to a terrible mishap that Angie and Nick must cover up.

When Bree begins to fall for Karl, she decides it is time to break things up before they get way too serious. However, Karl isn't willing to let her go that easily, and makes her a proposition. In the meantime, Juanita says a bad word during a school play and Gabrielle is attacked by the school's principal (guest star Marianne Muellerleile), which leads her to respond and ultimately get her daughter out of the school, whereas Lynette learns her husband is cheating during mid-term. Katherine pretends to be on Susan's side to get to Mike, and Angie hides some secrets regarding her mother...

Susan believes Katherine may have been Julie’s assailant, but Lynette has her own suspicions regarding who may have strangled her. In the meantime, Gabrielle struggles to homeschool her daughter Juanita. The Bolens invite the Hodges over for dinner, and Angie confronts her husband about a secret he seems to be withholding from her.

Susan discovers a surprising connection between her husband and Katherine Mayfair, which leads her to question her relationship with Mike. Meanwhile, Gabrielle will stop at nothing to get her daughter Juanita in Catholic school, and Lynette’s pregnancy becomes impossible to hide. As Bree tries to hide her infidelity, Angie uncovers the truth about Orson and Bree’s less than perfect marriage.

Angie decides it’s time for her and her family to leave Wisteria Lane considering another attack may occur, while Bree’s affair with Karl becomes harder to keep a secret and results in Bree and Susan literally up in each other’s arms. Meanwhile, a rift with Gaby is caused by Lynette’s pregnancy, and the result of a confrontation between Mike and Katherine is a harmful and unexpected blow.

Gabrielle and Lynette’s friendship is on the brink of collapse, whereas Bree and Orson come to an agreement about their marriage. Meanwhile, Susan hatches a plan to help an irrational Katherine, and Danny’s vital mistake might cost Angie her freedom. In the meantime, Christmas cheer is curtailed when disaster strikes, as a plane crashes down on Wisteria Lane, putting lives in peril.

In the aftermath of the plane crash, the residents of Wisteria Lane think about what their lives might have been like had they made different choices

Susan turns up the heat for Mike while Bree learns that it won't be easy to take back the hurt she's caused Orson. Meanwhile, Lynette uncovers the true intentions Tom has, while Gaby is forced to examine the feelings she's suppressed about her "heritage".

While Lynette balks at the idea of seeing a therapist for couples, Katherine visits her own psychiatrist. Meanwhile, Gaby and Susan decide to find out which of their kids are in the smartest group at school, while Angie is less than enthusiastic about Danny's new girlfriend.

Gaby and Angie challenge each other's parenting skills, Susan befriends a stripper and takes her under her wing, Lynette and Tom argue the merits of their new therapist, and a concerned Bree keeps a watchful eye on Orson for fear he may take his own life.

Former exotic dancer Robin will have a profound effect on Susan's friends -- with three teenage boys at home, Lynette will keep a watchful eye; Bree picks up a few tricks to engage Orson; Gaby looks for help with troublesome niece Ana; and Katherine will find a friendly companion.

When Celia comes down with the chicken pox, Gaby must keep her distance. Having never had the chicken pox herself, Gaby stays with Tuc and Bob and is reminded of what it's like to be single again; Lynette and Tom forget Penny's birthday; Bree hires a promising new employee; Susan cheats on Mrs. McKluskey; Katherine makes a surprising discovery; and Angie grows concerned over Danny's disappearance.